Albumin–alginate-coated microspheres: Resistance to steam sterilization and to lyophilization

M Callewaert, D Laurent-Maquin… - International journal of …, 2007 - Elsevier
The paper describes the effect of different thermal treatments on the morphology and
binding properties of particles prepared using a transacylation reaction between two
biocompatible polymers, namely propylene glycol alginate and human serum albumin.
Compared to control alginate gel microspheres, albumin–alginate covalent network offers a
better resistance to the microspheres towards freezing, lyophilization and sterilization. The
binding properties for methylene blue were not altered by the treatments. Moreover, stability …
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